The interaction between ischemia from vasospastic angina or myocardial bridging and the Brugada syndrome electrophysiological substrate may increase susceptibility to life-threatening ventricular tachyarrhythmias.
May link bridging or spasm to VF in Brugada; hypothesis-generating case leaves causal interaction and management implications open.
This report describes a case of an unusual association between vasospastic angina, coronary myocardial bridging, and Brugada syndrome. The patient complained of chest pain followed by rhythmic palpitation and syncope. Brugada syndrome ECG markers were documented with transient ST-segment elevation in lateral leads. A coronary angiogram showed a myocardial bridging in the left anterior descending artery and coronary vasospasm was reproduced after intracoronary ergonovine injection in the circumflex coronary artery. Ventricular fibrillation was induced by programmed electrical stimulation. The described association can be important because interaction between ischemia and Brugada syndrome electrophysiological substrate could modulate individual susceptibility to life-threatening ventricular tachyarrhythmias.
No takes yet. Share an insight, caveat, or question.
Imazio et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: