Why the study?
Diabetes mellitus is a major risk factor for coronary artery disease, prompting assessment of how CAD severity relates to fasting blood sugar and HbA1c.
Is higher fasting blood sugar and HbA1c associated with increased severity of coronary artery disease (SYNTAX score) in adult patients undergoing coronary angiography?
Is higher fasting blood sugar and HbA1c associated with increased severity of coronary artery disease (SYNTAX score) in adult patients undergoing coronary angiography?
Elevated fasting blood sugar, HbA1c, and the presence of metabolic syndrome or diabetes are significantly associated with more complex and severe coronary artery disease as measured by the SYNTAX score.
Answers are grounded in this paper and cite their sources.
Higher FBS/HbA1c associate with greater SYNTAX scores in diabetics; leaves open whether glycemic control alters CAD severity.
Background: Diabetes mellitus (DM) is one of the major risk factors for coronary artery disease (CAD). Accordingly, in this study, attempt is to be made to assess the association of severity of CAD by angiography with fasting blood sugar (FBS) and hemoglobin A1c (HbA1c). Aims and Objectives: To evaluate coronary angiographic abnormalities in patients of Diabetes. Materials and Methods: Six hundred adult patients of both sexes admitted in the department of cardiology, Nil Ratan Sircar Medical College and Hospital, Kolkata with ischemic heart disease from June 2018 to February 2020 underwent FBS and glycosylated Hb besides other routine tests. Coronary angiography done and the severity of CAD was assessed by SYNTAX SCORE was correlated. It is an observational, Cross-sectional hospital-based single center study. Results: Syntax scores were highest in the body mass index ≥30 kg/m2 group (16.5). Patients with Syntax score ≥33 are found to have much higher values of HbA1c (6.8±1.3) compared to those with Syntax score of ≤22 (6.4±1.8). Fasting blood glucose level in Syntax score ≥33 group has been found to be significantly higher compared to the group of Syntax score ≤22. Conclusion: Patients having DM and/or metabolic syndrome are found to have more severe form of CAD than those who don’t have either of these.
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Saha et al. (2022) studied this question.
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