May 1, 1995Journal of VirologyOpen Access

Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger

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Structured PICO

Population

Polyomavirus large tumor antigen (LT) and synthetic peptides/fusion proteins containing its potential C2H2 zinc binding element

Intervention

Site-directed mutagenesis of conserved residues (C-452, C-455, H-465, H-469, H-472)

Comparator

Wild type polyomavirus large T antigen

Outcome

Zinc binding ability, viral DNA replication function, and self-associationsurrogate

The conserved zinc finger element in polyomavirus large T antigen is essential for self-association and subsequent viral DNA replication.

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May guide antiviral targeting of zinc finger motifs; hypothesis-generating for human polyomavirus applications pending further validation.

Rose et al. (1995) studied this question.

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May guide antiviral targeting of zinc finger motifs; hypothesis-generating for human polyomavirus applications pending further validation.