Why the study?
Do statins prevent new-onset heart failure or reduce mortality in patients with coronary heart disease or established heart failure?
Do statins prevent new-onset heart failure or reduce mortality in patients with coronary heart disease or established heart failure?
Statins may be beneficial for preventing heart failure in high-risk CHD patients and reducing mortality in those with established HF, supporting their use in patients with cardiovascular disease, dyslipidemia, or diabetes.
Hypothesis-generating for statin benefits in CHD and established HF; dedicated prospective trials needed before practice change.
Statins are effective in the prevention of coronary heart disease (CHD), a leading cause of heart failure (HF). Secondary analyses from 11 randomized clinical trials of patients with high-risk acute or stable coronary heart disease, but without HF, suggest that statins may prevent new-onset HF or HF-related hospitalization. In persons with established HF, several cohort studies found an approximate 35% relative risk reduction in all-cause mortality. While ongoing randomized clinical trials will help to determine the efficacy of statins in persons with established HF, it is reasonable to consider this class of medications in patients with a history of cardiovascular disease, dyslipidemia or diabetes mellitus, and who have either developed, or who remain at risk of, HF.
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Udell et al. (2006) studied this question.
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