What question did this study set out to answer?

To evaluate the placental transfer and fetal cord blood concentrations of the antifibrinolytic inhibitor AMCA following intravenous maternal administration prior to delivery.

January 1, 1970Acta Obstetricia Et Gynecologica Scandinavica

Human Placental Transfer of an Antifibrinolytic Agent (AMCA)

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Authors

SKStig KullanderOlgahospital INInga Marie NilssonNovartis (United States)

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Implication

Pharmacokinetic study demonstrates transplacental transfer of AMCA to cord blood during delivery, suggesting maternal dosing may protect against neonatal hemorrhage.

Key Points

To evaluate the placental transfer and fetal cord blood concentrations of the antifibrinolytic inhibitor AMCA following intravenous maternal administration prior to delivery.
Administered intravenous AMCA at a dose of 0.01 g/kg body weight to N=12 mothers prior to Caesarean section delivery.
Measured maternal and umbilical cord blood drug concentrations immediately post-delivery using high-voltage paper electrophoresis and photometric detection of ninhydrin complexes.
AMCA crossed the human placenta, reaching umbilical cord blood concentrations between 4 and 31 μg/ml immediately after delivery.
Achieved fetal drug levels that may provide effective maternal-route prophylaxis against pulmonary or intracranial fibrinolytic bleeding in premature neonates.

Cite This Study

Kullander et al. (1970) studied this question.

synapsesocial.com/papers/6a70e39df44fa9f079dea007 https://doi.org/10.3109/00016347009157244

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Implication

Pharmacokinetic study demonstrates transplacental transfer of AMCA to cord blood during delivery, suggesting maternal dosing may protect against neonatal hemorrhage.

Human Placental Transfer of an Antifibrinolytic Agent (AMCA)

Discussion

Member takes

Implication

Key Points

Cite This Study

Human Placental Transfer of an Antifibrinolytic Agent (AMCA)

Discussion

Member takes

Implication

Key Points

Cite This Study

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