Why the study?
Does endothelin receptor blockade restore renal blood flow autoregulation in rats fed a high-salt diet?
Population
Male Sprague-Dawley rats (270-330 g) and ETB receptor-deficient rats (with transgenic controls).
Comparison
High-salt diet for 14 days with ETA receptor… vs Normal-salt diet (0.8% NaCl) for 14 days.
Design
Preclinical
Follow-up
14 days
Authors
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HS diet may enhance ET-1 receptor activation in rat renal microvessels; leaves open translation to human salt-sensitive RBF autoregulation.
Does endothelin receptor blockade restore renal blood flow autoregulation in rats fed a high-salt diet?
Endogenous endothelin-1, acting through ETB and ETA receptors, contributes to the blunted renal autoregulatory behavior observed with a high-salt diet.
Fellner et al. (2015) studied this question.
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