Key result
Renal ET(B) function is impaired in male Ang II hypertensive rats due to reduced ET(B) binding sites, whereas it is preserved in female rats.
Population
Male and female rats, normotensive controls and Angiotensin II-induced hypertensive models
Comparison
Acute intramedullary infusion of the ET agonist… vs Normotensive control rats and baseline…
Design
Preclinical
Follow-up
2 weeks
Authors
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May explain sex differences in hypertension; leaves open translation to human ET(B) therapies.
p-value: p=<0.05
Renal ET(B) receptor function and binding are impaired in male but preserved in female Angiotensin II hypertensive rats, suggesting a mechanism for sex differences in hypertension.
Kittikulsuth et al. (2011) studied Angiotensin II hypertension. Angiotensin II infusion vs. Normotensive controls was evaluated on Sodium excretion after ET(B) agonist sarafotoxin 6c (p=<0.05). Renal ET(B) function is impaired in male Ang II hypertensive rats due to reduced ET(B) binding sites, whereas it is preserved in female rats.
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