Why the study?
Does a recent history of hospital admission increase the prevalence of HPF4 antibodies in patients presenting with acute coronary syndromes?
Does a recent history of hospital admission increase the prevalence of HPF4 antibodies in patients presenting with acute coronary syndromes?
Approximately 7% of ACS patients have pre-existing HPF4 antibodies, and the incidence is tripled in those recently hospitalized, suggesting a higher risk for heparin-induced thrombocytopenia upon heparin re-exposure.
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May warrant caution with heparin re-exposure in recently hospitalized ACS patients; leaves open value of pre-treatment antibody screening.
Francis et al. (2004) studied this question.
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