January 1, 2011Cardiovascular DiabetologyOpen Access

Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway

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Why the study?

Does GLP-1 enhance cardiac L-type Ca2+ currents in canine cardiomyocytes?

Structured PICO

Does GLP-1 enhance cardiac L-type Ca2+ currents in canine cardiomyocytes?

Population

Enzymatically isolated cardiomyocytes from adult canine left ventricles

Intervention

Extracellular perfusion of GLP-1 (7-36 amide) at 5 nM

Outcome

Cardiac voltage-gated L-type Ca2+ current (I(Ca)) and action potential durationsurrogate

GLP-1 enhances cardiac L-type Ca2+ currents and prolongs action potential duration in canine cardiomyocytes via the cAMP-dependent protein kinase A pathway.

Discussion

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Implication

GLP-1 effects on canine cardiomyocyte currents warrant human studies; does not change current clinical practice.

Cite This Study

Xiao et al. (2011) studied this question.

synapsesocial.com/papers/6a70e532b5c1fe5ca9dfc547 https://doi.org/10.1186/1475-2840-10-6

Topics

GLP-1 agonists cardiovascular outcomes

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Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway

Structured PICO

Discussion

Implication

Cite This Study

Topics

Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider