Role of the TSLP and its Receptor in the Treatment of Asthma

Thymic stromal lymphopoietin (TSLP) is a crucial cytokine in initiating and regulating immune responses.Various cell types, including epithelial cells, fibroblasts, and dendritic cells, synthesize TSLP.TSLP activates dendritic cells, which subsequently promote the differentiation of T cells into T-helper 2 (T H 2) cells, a subset of T cells that produce cytokines involved in allergic responses.Genetic studies have linked TSLP to the development of asthma and other inflammatory disorders, indicating its importance in the pathogenesis of these diseases.Inhibiting the TSLP-TSLR axis has been suggested as a precision medicine strategy for treating several phenotypes and endotypes of asthma.Tezepelumab is a human monoclonal antibody that selectively binds to TSLP, thereby blocking its interaction with its heterodimeric receptor, reducing inflammation in the airways, and improving asthma symptoms.