Population
Mouse brain tissue and rat neuroendocrine PC-12 cells
Design
Preclinical
Authors
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May link Delta4-(P)RR to X-linked mental retardation and epilepsy; animal data leave open human relevance.
The Delta4-(P)RR mutation exerts a dominant-negative effect on normal (P)RR, inhibiting neuronal differentiation and providing a potential mechanism for its association with X-linked mental retardation and epilepsy.
Contrepas et al. (2009) studied this question.
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