Synthesis of Substituted Pyrazole Derivatives: Evaluation of their Anti- Mycobacterial Activity

Various highly substituted pyrazoles were synthesized from the corresponding starting material using HATU reagent. We produce these biologically interesting heterocycles in high yields. All the synthesized compounds are tested against anti-mycobacterial activity. Among them, 9, 10, 12 and 25 are identified as lead molecules. In particular, 9, and 12 are found to display promising activity.