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Inability to produce penicillinase is not a determining factor in the sensitivity of an organism to penicillin. However, penicillinase-producing bacteria are not likely to be highly susceptible to penicillin. Development of resistance to penicillin by a bacterium is not associated with acquisition by the bacterium of the ability to produce penicillinase.
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Bondi et al. (1944) studied this question.
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