[Effects of adipose-derived stem cells and non-methylated CpG-oligodeoxynucleotides on peripheral blood CD4⁺CD25⁺ regulatory T cells in young mice with food allergy].

This is the authors' abstract. We don't add key points for this paper.

OBJECTIVE: regulatory T (Treg) cells in young mice with food allergy, as well as their immune intervention effects. METHODS: Treg cells. Hematoxylin and eosin staining was used for the pathological analysis of the jejunum. RESULTS: Treg cells than the allergic group (P<0.05); there were no significant differences between these two groups or between them and the control group (P>0.05). Pathological results showed structural damage and edema in the jejunal villi, a large number of eosinophils, and lymphocyte infiltration in the allergic group, while the ADSC treatment group and the CpG-ODN treatment group had less structural damage and edema in the jejunal villi, a lower number of eosinophils, and less lymphocyte infiltration. CONCLUSIONS: Treg cells and reduce the level of OVA-IgE. They may be associated with the induction of immune tolerance and these two treatment have comparable effects. Detailed mechanisms of action still need further investigation.