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Hypothesis-generating link between FTO variant and BED in obesity; prospective validation required before any clinical role.
Obesity is a major health problem in the twenty-first century. Recent research shows that, among people with severe obesity, there is a sub-population that does not respond to behavioral treatment for weight loss. This group presents a type of eating disorder known as Binge Eating Disorder (BED). Recent studies indicate a link between obesity in adults and the rs9939609 polymorphism of the FTO gene. A frequent association of obesity and BED has also been found. Variations in the gene, including the rs9939609 polymorphism, have been associated with obesity and diabetes. To identify whether there is any associaton between the rs9939609 polymorphism of FTO, and the presence of BED in severely obese patients.
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Horvath et al. (2015) studied this question.
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