Why the study?
Low quality of computed tomography data and tachycardia complicate the interpretation of measured or simulated haemodynamic indices.
Does a novel computational algorithm accurately evaluate terminal coronary resistances and how does tachycardia affect haemodynamic indices?
Does a novel computational algorithm accurately evaluate terminal coronary resistances and how does tachycardia affect haemodynamic indices?
Answers are grounded in this paper and cite their sources.
A novel computational algorithm accurately evaluates terminal coronary resistances in truncated models, demonstrating that tachycardia can lead to over- or underestimation of stenosis significance using FFR, CFR, and iFR.
Haemodynamic indices are widely used in clinical practice when deciding on a particular type of treatment. Low quality of the computed tomography data and tachycardia complicate interpretation of the measured or simulated values. In this work, we present a novel approach for evaluating resistances in terminal coronary arteries. Using 14 measurements from 10 patients, we show that this algorithm retains the accuracy of 1D haemodynamic simulations in less detailed (truncated) geometric models of coronary networks. We also apply the variable systole fraction model to study the effect of elevated heart rate on the values of fractional flow reserve (FFR), coronary flow reserve (CFR) and instantaneous wave-free ratio (iFR). We conclude that tachycardia may produce both overestimation or underestimation of coronary stenosis significance.
No takes yet. Share an insight, caveat, or question.
Simakov et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: