Atrogin-1 exacerbates ischemia/reperfusion-induced apoptosis in cardiomyocytes by degrading MKP-1 and sustaining JNK activation, identifying a potential cellular mechanism and therapeutic target for ischemic injury.
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Suggests Atrogin-1 inhibition to limit I/R apoptosis; hypothesis-generating in animal models, clinical translation remains open.
Xie et al. (2009) studied this question.
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