Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial fibrillation
Why the study?
Are non-synonymous NPPA single nucleotide polymorphisms rs5063 and rs5065 associated with the development of early-onset atrial fibrillation in populations of European ancestry?
Population
3,066 individuals of European ancestry from two North American cohorts, comprising 620 patients with…
Comparison
Presence of non-synonymous NPPA single… vs Healthy controls without early-onset atrial…
Design
Case-control
Authors
Discussion
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Member takes
Implication
No association with these NPPA variants; leaves open rarer variant or ancestry-specific effects on early-onset AF.
Structured PICO
Are non-synonymous NPPA single nucleotide polymorphisms rs5063 and rs5065 associated with the development of early-onset atrial fibrillation in populations of European ancestry?
P
Population
3,066 individuals of European ancestry from two North American cohorts, comprising 620 patients with early-onset atrial fibrillation and 2,446 healthy controls.
I
Intervention
Presence of non-synonymous NPPA single nucleotide polymorphisms rs5063 and rs5065
C
Comparator
Healthy controls without early-onset atrial fibrillation
O
Outcome
Association with the development of atrial fibrillation
Common non-synonymous genetic variants rs5063 and rs5065 within the NPPA gene are not associated with the development of early-onset atrial fibrillation in North American populations of European ancestry.
Cite This Study
Roberts et al. (2010) studied this question.