Population
Women (normal, hyperstimulated with gonadotropins, pregnant, and one with ovarian failure)
Design
Review
Authors
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May support ovarian prorenin in reproductive physiology; leaves open clinical relevance in fertility or pregnancy.
The review highlights that the ovaries synthesize and secrete prorenin in response to gonadotropic hormones, suggesting a local renin-angiotensin system in human reproductive function.
Sealey et al. (1987) studied this question.
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