Influence of acute myocardial depression on left ventricular stiffness and its elastic and viscous components.
Why the study?
Does acute myocardial depression alter left ventricular stiffness and its elastic and viscous components in a canine model?
Population
19 dogs placed on cardiopulmonary bypass
Comparison
Acute myocardial depression induced by coronary… vs Baseline state prior to induction of myocardial…
Design
Preclinical
Authors
Discussion
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Implication
Acute myocardial depression may increase viscous LV stiffness in canine models; leaves open translation to human HF assessment or therapy.
Structured PICO
Does acute myocardial depression alter left ventricular stiffness and its elastic and viscous components in a canine model?
P
Population
19 dogs placed on cardiopulmonary bypass
I
Intervention
Acute myocardial depression induced by coronary artery ligation, propranolol, or pentobarbital
C
Comparator
Baseline state prior to induction of myocardial depression
O
Outcome
Ventricular stiffness and its elastic and viscous componentssurrogate
Acute myocardial depression increases total ventricular stiffness primarily through an increase in its viscous component rather than its elastic component.
Cite This Study
Templeton et al. (1975) studied this question.