Influence of Temperature on the Mechanical Properties of Cardiac Muscle
Key result
Increasing temperature from 33° to 40°C in vivo and 22° to 40°C in vitro inversely affected total myocardial stiffness, with the viscous component being more sensitive to temperature changes.
Population
12 intact dog hearts on whole-heart bypass and 8 isolated cat papillary muscles
Comparison
Temperature elevation vs Lower baseline temperatures
Design
Preclinical
Authors
Discussion
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Implication
Myocardial stiffness temperature sensitivity remains preclinical; leaves open human diastolic effects and therapeutic relevance.
Structured PICO
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Population
12 dogs on whole-heart bypass and 8 cat papillary muscles used to study the influence of temperature on cardiac muscle stiffness.
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Intervention
Temperature elevation (from 33° to 40°C in vivo and from 22° to 40°C in vitro)
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Comparator
Lower baseline temperatures
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Outcome
Total myocardial stiffness and its elastic and viscous componentssurrogate
This preclinical study demonstrates that myocardial stiffness is inversely related to temperature, primarily driven by changes in the viscous component.
Cite This Study
Templeton et al. (1974) studied Cardiac muscle mechanical properties (n=20). Temperature changes vs. Baseline temperatures was evaluated on Total myocardial stiffness and its elastic and viscous components. Increasing temperature from 33° to 40°C in vivo and 22° to 40°C in vitro inversely affected total myocardial stiffness, with the viscous component being more sensitive to temperature changes.