Key result
Higher temperatures reduce relaxation load dependence, as mechanical kinetics are more temperature-sensitive than SR Ca2+ handling.
Population
Rat right ventricular papillary muscles (n = 7)
Comparison
Temperature changes vs Different temperatures compared to each other
Design
Preclinical
Authors
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Temperature effects on myocardial relaxation should not change practice; leaves open translation of differential mechanical versus Ca2+ sensitivity to intact hearts.
In mammalian myocardium, mechanical kinetics of relaxation are more sensitive to temperature changes than sarcoplasmic reticulum calcium handling.
Dobrunz et al. (1994) studied this question. Temperature (24, 30, and 37 degrees C) vs. Different temperatures compared to each other was evaluated on Load dependence of relaxation (LDoR), T + dF/dt, and tau f. Increasing temperature attenuated load dependence of relaxation and increased the ratio of T + dF/dt to tau f, indicating mechanical kinetics are more sensitive to temperature than SR Ca2+ handling.
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