What question did this study set out to answer?

To evaluate the relative efficacy of adding androgen suppression therapy to radiation therapy compared with radiation therapy alone in men with clinically localized prostate cancer.

September 13, 2000JAMA

Biochemical Outcome Following External Beam Radiation Therapy With or Without Androgen Suppression Therapy for Clinically Localized Prostate Cancer

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Authors

ADA.V. D’AmicoMillersville University

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Implication

Retrospective cohort study reveals reduced PSA failure risk with added androgen suppression in intermediate- and high-risk localized prostate cancer, indicating clear benefit in higher-risk disease.

Key Points

To evaluate the relative efficacy of adding androgen suppression therapy to radiation therapy compared with radiation therapy alone in men with clinically localized prostate cancer.
Retrospective cohort study of 1586 men treated between January 1989 and August 1999 with 3-dimensional conformal radiation therapy alone (n = 1310) or with 6 months of androgen suppression therapy (n = 276).
Assessed relative risk (RR) of prostate-specific antigen (PSA) failure stratified across low-, intermediate-, and high-risk groups defined by serum PSA, biopsy Gleason score, and clinical tumor stage.
Intermediate- and high-risk patients receiving combined radiation and androgen suppression experienced significantly lower rates of PSA failure versus radiation alone (intermediate-risk: RR 0.2, 95% CI 0.1-0.3, P < .001; high-risk: RR 0.4, 95% CI 0.2-0.8, P = .009).
Low-risk patients showed no statistically significant difference in 5-year PSA failure between radiation with or without androgen suppression therapy (RR 0.5, 95% CI 0.3-1.1, P = .09).

Cite This Study

A.V. D’Amico (2000) studied this question.

synapsesocial.com/papers/6a70f2a131a3df824329311a https://doi.org/10.1001/jama.284.10.1280

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Implication

Retrospective cohort study reveals reduced PSA failure risk with added androgen suppression in intermediate- and high-risk localized prostate cancer, indicating clear benefit in higher-risk disease.

Biochemical Outcome Following External Beam Radiation Therapy With or Without Androgen Suppression Therapy for Clinically Localized Prostate Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Biochemical Outcome Following External Beam Radiation Therapy With or Without Androgen Suppression Therapy for Clinically Localized Prostate Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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