Why the study?
The study aimed to investigate the altered expression signature of long non-coding RNAs, mRNAs, and deregulated pathways related to diabetic cardiomyopathy pathogenesis.
Does stimulation with glucose, endothelin-1, and cortisol alter long non-coding RNA and mRNA expression in human induced pluripotent stem cell-derived cardiomyocytes?
Population
Human induced pluripotent stem cell-derived human cardiomyocytes in vitro model
Comparison
Glucose (11 mM), endothelin-1 (10 nM), and cortisol (1 µM) stimulation vs control group
Design
In vitro microarray expression analysis
Authors
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Identifies dysregulated lncRNA-mRNA networks in hiPSC-CM diabetic stress model; leaves open in vivo relevance and therapeutic translation.
Does stimulation with glucose, endothelin-1, and cortisol alter long non-coding RNA and mRNA expression in human induced pluripotent stem cell-derived cardiomyocytes?
This study identifies specific long non-coding RNAs and mRNAs that are differentially expressed in an in vitro model of diabetic cardiomyopathy, highlighting potential regulatory mechanisms and therapeutic targets.
Pant et al. (2018) studied this question.
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