Population
Cultured adult rat cardiac fibroblasts
Comparison
C-type natriuretic peptide (CNP) vs Atrial natriuretic peptide and brain natriuretic…
Design
Preclinical
Authors
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Hypothesis-generating for CNP-mediated antifibrosis in fibroblasts; leaves open in vivo efficacy and clinical translation.
CNP is synthesized by and secreted from cardiac fibroblasts, acting as an autocrine regulator that suppresses fibroblast proliferation and extracellular matrix production to potentially protect against excessive cardiac fibrosis.
Horio et al. (2003) studied this question.
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