Key result
Recalcification and kaolin clotting mixture tests best detect lupus anticoagulant, present in ~49% of SLE.
Observational (n=66)
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Sixty-six SLE patients were studied for the presence of lupus type circulating anticoagulant. Forty-nine percent of them showed activity of this anticoagulant. The sensitivity of various coagulation tests was compared. Recalcification time was found to be the most sensitive screening test and the kaolin clotting time mixture test, the best for determining the presence of the anticoagulant. Tissue thromboplastin inhibition test detected only half of the patients in whom the anticoagulant was found by recalcification time and kaolin clotting time mixture test. APTT, using 2 different reagents, resulted in 73% and 52% false negatives. A numerical index for determining the presence of the anticoagulant and its quantitative evaluation is suggested. The association between thromboembolic events, recurrent abortions and the different coagulation tests is shown.
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Rosner et al. (1987) conducted an observational in Systemic lupus erythematosus (SLE) (n=66). Coagulation tests (recalcification time, kaolin clotting time mixture test, tissue thromboplastin inhibition test, APTT) was evaluated on Detection of lupus type circulating anticoagulant activity. Recalcification time and kaolin clotting time mixture tests best detected lupus anticoagulant, while APTT yielded 52%-73% false negatives.
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