The chemical, physical, and biological properties of left-handed DNA have been studied using polymers, restriction fragments, and recombinant plasmids with established sequences. Our goal in the past several years has been to determine the existence of left-handed DNA in biological systems as part of our evaluation of the involvement of DNA microheterogeneity in gene regulation. General aspects of the involvement of DNA structure in gene expression have been reviewed recently (Wells et al. 1980b).
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Wells et al. (1983) studied this question.