Why the study?
Does atorvastatin alter the anticoagulant activity of warfarin in patients chronically maintained on warfarin?
Does atorvastatin alter the anticoagulant activity of warfarin in patients chronically maintained on warfarin?
Short-term administration of high-dose atorvastatin does not significantly alter warfarin's anticoagulant effect, suggesting no routine dose adjustment is necessary.
Answers are grounded in this paper and cite their sources.
Short-term atorvastatin may not necessitate warfarin dose adjustment; leaves open confirmation in randomized trials.
Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustment in warfarin dosing should not be necessary.
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Stern et al. (1997) studied this question.
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