What question did this study set out to answer?

To review the emergence of antimicrobial resistance in bacterial pathogens and its historical impact on the clinical effectiveness of early antibiotic therapies.

November 7, 1996New England Journal of Medicine

Antimicrobial-Drug Resistance

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Authors

HGHoward S. GoldBeth Israel Deaconess Medical Center RMRobert C. MoelleringHarvard University

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Implication

Narrative review demonstrates rapid bacterial resistance mechanisms against antimicrobial drugs in clinical settings, highlighting challenges in treating staphylococcal infections.

Key Points

To review the emergence of antimicrobial resistance in bacterial pathogens and its historical impact on the clinical effectiveness of early antibiotic therapies.
Reviewed historical and clinical patterns of bacterial adaptation following the introduction of antimicrobial therapies.
Evaluated specific resistance mechanisms, focusing on beta-lactamase production and pathogen dissemination from hospital to community environments.
Bacterial pathogens rapidly developed resistance mechanisms, such as beta-lactamase production in Staphylococcus aureus, diminishing the clinical utility of penicillin for severe infections.
Antimicrobial-resistant strains frequently emerged first among hospitalized patients before spreading into the broader community.

Cite This Study

Gold et al. (1996) studied this question.

synapsesocial.com/papers/6a70f825febe604dd709b7f3 https://doi.org/10.1056/nejm199611073351907

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Implication

Narrative review demonstrates rapid bacterial resistance mechanisms against antimicrobial drugs in clinical settings, highlighting challenges in treating staphylococcal infections.

Antimicrobial-Drug Resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

Antimicrobial-Drug Resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

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