Comparison of Nonclassic and Classic Phenotype of Hypertrophic Cardiomyopathy Focused on Prognostic Cardiac Magnetic Resonance Parameters: A Single-Center Observational Study

Figures

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  Figure 1. HCM phenotypes and stages in the study group according to Olivotto et al., 2012 [6].

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  Figure 2. HCM risk score (hypertrophic cardiomyopathy European Society of Cardiology risk score) in NCP (nonclassic phenotype) and CP (classic phenotype) patients. Data presented in boxplot as median values, interquartile range, and minimal and maximal values.

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  Figure 3. LGE (late gadolinium enhancement) extent comparison between nonclassic and classic phenotypes. Data presented in boxplot as median values, interquartile range, and minimal and maximal values.

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  Figure 4. (a) EF (ejection fraction) distribution in the study group, EF = 65% was the cutpoint splitting the study subgroups into NCP (nonclassic phenotype) and CP (classic phenotype); (b) quantitative LGE (late gadolinium enhancement) distribution among the study groups. (c) Correlation of EF and LGE% (late gadolinium enhancement expressed as the percent of myocardial mass); LGE% = 5 and EF = 65% split the patient group into four quarters.

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  Figure 5. (a) Segmental myocardial thickness—in NCP (nonclassic phenotype), greater mostly in midsegments (marked as yellow); (b) segmental LGE (late gadolinium enhancement) distribution. The usual locations of LGE areas in HCM (hypertrophic cardiomyopathy) were insertion points of the right ventricle and focal areas in hypertrophied regions. In the NCP group, the enhancement was more frequent beyond the insertion points, indicating more extensive distribution (marked as green).

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  Figure 6. Myocardial contraction fraction comparison between nonclassic and classic phenotypes. Data presented in boxplot as median values, interquartile range, and minimal and maximal values.

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  Figure 7. LA EF% (left atrial emptying fraction) comparison between nonclassic and classic phenotypes. Data presented in boxplot as median values, interquartile range, and minimal and maximal values.

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  Figure 8. Correlation between maximal velocities measured in left ventricular outflow tract (m/s) and (a) the LVOT/Ao (left ventricular outflow tract diameter/aortic valve diameter) ratio; (b) the AML/LVOT (anterior mitral leaflet length/left ventricular outflow tract diameter) ratio.