What question did this study set out to answer?

To review the clinical manifestations, hematologic parameter alterations, and disease course in patients with beta-thalassemia/hemoglobin E.

November 1, 2000The American journal of pediatric hematology/oncology

Clinical Manifestation of β-Thalassemia/Hemoglobin E Disease

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To review the clinical manifestations, hematologic parameter alterations, and disease course in patients with beta-thalassemia/hemoglobin E.
Retrospective analysis of clinical manifestations in 378 patients with beta-thalassemia/hemoglobin E attending a hematology clinic at Siriraj Hospital between 1957 and 1982.
Most patients presented with clinical symptoms by 10 years of age, with common presenting complaints including gastrointestinal tract disturbances (34.6%), respiratory tract infections (21.8%), and cardiovascular complications (11.9%), while 26.5% underwent splenectomy.
Mortality occurred predominantly between 20 and 40 years of age (67%), with congestive heart failure and Gram-negative septicemia identified as the primary causes of death resulting from chronic anemia and iron overload.

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Implication

Retrospective study reveals high rates of severe complications and early mortality in beta-thalassemia/hemoglobin E, highlighting the impact of chronic anemia and iron overload.

Cite This Study

Fucharoen et al. (2000) studied this question.

synapsesocial.com/papers/6a70f89426770c2b8de0d9cf https://doi.org/10.1097/00043426-200011000-00022

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Implication

Retrospective study reveals high rates of severe complications and early mortality in beta-thalassemia/hemoglobin E, highlighting the impact of chronic anemia and iron overload.

Clinical Manifestation of β-Thalassemia/Hemoglobin E Disease

Key Points

Discussion

Implication

Cite This Study

Clinical Manifestation of β-Thalassemia/Hemoglobin E Disease

Key Points

Discussion

Implication

Cite This Study

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