Population
IL-10 null and wildtype mice undergoing reperfused infarction protocols, and stimulated murine cardiac…
Comparison
IL-10 gene disruption and IL-10 pre-incubation vs Wildtype (WT) mice and untreated fibroblasts
Design
Preclinical
Authors
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IL-10 is non-critical for post-MI healing in mice; leaves open its relevance to human inflammation resolution.
IL-10 signaling plays a non-critical role in the suppression of inflammatory mediators, resolution of inflammation, and fibrous tissue deposition following myocardial infarction in mice.
Zymek et al. (2006) studied this question.
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