Connection of Intraoperative Hemolysis with the Development of Cardiac Rhythm Disturbances

The use of cardiopulmonary bypass in coronary artery bypass grafting (CABG) surgery can lead to red blood cell damage (hemolysis). Postoperative arrhythmias, such as atrial fibrillation, are frequent and serious complications after CABG. However, the relationship between the hemolysis that occurs during the surgery intraoperative hemolysis and the subsequent development of arrhythmias is not well-understood. This study will examine the connection between the level of IOH and the incidence of cardiac rhythm disturbances in patients with coronary artery disease who have undergone CABG surgery. The mechanisms causing arrhythmias after CABG are complex and involve various factors including changes in blood flow, the damage caused by restoring blood flow after cardiopulmonary bypass, and oxidative stress. Clarifying the role of surgery intraoperative hemolysis could help improve prevention and treatment strategies for these potentially dangerous complications. To establish the connection of IOH with the development of cardiac rhythm disturbances in patients with coronary artery disease after coronary shunting in conditions of cardiopulmonary bypass (CB). All patients underwent CB surgery in a planned manner under IR conditions. According to the level of free hemoglobin [Hb] in blood plasma, which is a marker of the degree of IOH, patients are divided into three groups: group 1 – without IOH (Hb≤ 0.1 g/l), n=43, group 2 - with low IOH (lIOH) - with [Hb]>0.1g/l and <0.5 g/l, n=42, group 3 – with a high IOH (hIOH) corresponded to [Hb] ≥0.5 g/l, n=38.