Predicting of Early Cardiovascular Complications After Coronary Artery Bypass Graft Surgery

Reconstructive heart surgeries, like coronary artery bypass grafting (CABG), carry a risk of significant complications, including death. These complications encompass a range of cardiovascular issues, including CABG-related myocardial infarction, worsening heart failure, arrhythmias. This study aimed to develop a method for predicting these early postoperative complications in patients undergoing CABG. The prediction model was based on the relationship between hemolysis, changes in iron levels, markers of oxidative stress, and nitric oxide levels. The study's approach draws upon earlier investigations, which looked at the relationship between complications following CABG and: intraoperative hemolysis, changes in iron transport and storage, oxidative stress levels, and stable nitric oxide metabolites. This research built on that foundation to create a more comprehensive understanding and prediction method. This study employed a multi-faceted approach to investigate the relationship between intraoperative hemolysis and the development of early postoperative cardiac complications after CABG. A total of 123 patients with coronary artery disease (CAD), who underwent CABG, were categorized into three groups based on the degree of IOH, measured by free hemoglobin (Hb) levels in blood plasma at the conclusion of the CABG procedure using a Неmo Cue Plasma/Low Hb analyzer. Groups were: no significant intraoperative hemolysis (n=43), low intraoperative hemolysis (n=42), and high intraoperative hemolysis (n=38).