Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synthase
Why the study?
Does intensive glycaemic control improve endothelial function in patients with type-2 diabetes mellitus?
Population
24 patients with type-2 diabetes mellitus (DM)
Comparison
Intensive treatment for tight glycaemic control vs Conventional therapy
Design
Cohort
Authors
Discussion
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Member takes
Implication
Intensive glucose control was associated with improved endothelial function in T2DM; hypothesis-generating for TNF-alpha/ADMA mediation, needs RCTs before practice change.
Structured PICO
Does intensive glycaemic control improve endothelial function in patients with type-2 diabetes mellitus?
P
Population
24 patients with type-2 diabetes mellitus (DM)
I
Intervention
Intensive treatment for tight glycaemic control (hospitalized)
C
Comparator
Conventional therapy
O
Outcome
Flow-mediated, endothelium-dependent dilation (FMD) of brachial arteriessurrogate
Intensive glycemic control in type-2 diabetes improves endothelial function, potentially through the reduction of TNF-alpha and ADMA levels.
Cite This Study
Yasuda et al. (2006) studied this question.