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INTRODUCTION: Previous studies showed that patients with acute alcohol hallucinosis had significantly lower levels of the inhibitory amino acid neurotransmitter, glycine. METHODS: A placebo-controlled, double-blind study of glycine in 40 patients with acute alcohol hallucinosis. Treatment duration was 7 days with no other psychotropic medication. RESULTS: The 20 patients randomised to the active drug (700 mg glycine sublingually) demonstrated a significant decrease in severity of hallucinosis compared to the 20 patients receiving placebo. CONCLUSION: The positive effects of glycine may be related to an altered balance between excitatory and inhibitory amino acid neurotransmitters.
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Aliyev et al. (2005) studied this question.
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