We propose a mechanism for the initiation of cell motility that is based on myosin-induced contraction and does not require actin polymerization. The translocation of a cell is induced by symmetry breaking of the motor-driven flow, and the ensuing asymmetry gives rise to a steady motion of the center of mass of a cell. The predictions of the model are consistent with observations on keratocytes.
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Recho et al. (2013) studied this question.
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