May 1, 2002Journal of Biological ChemistryOpen Access

Novel Mode of Action of Angiotensin I Converting Enzyme Inhibitors

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Population

Endothelial or transfected cells expressing the human bradykinin B(1) receptor

Design

Preclinical

Authors

TITatjana IgnjatovicUniversity of Illinois Urbana-Champaign FTFulong TanUniversity of Illinois Urbana-Champaign VBViktor BrovkovychUniversity of Illinois Chicago

Discussion

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Implication

May explain ACE inhibitor effects via B1 receptor NO release; leaves open clinical relevance in humans.

Structured PICO

Population

Endothelial or transfected cells expressing the human bradykinin B(1) receptor

Intervention

Enalaprilat and other ACE inhibitors in nanomolar concentrations

Outcome

Activation of bradykinin B(1) receptors, elevation of intracellular Ca(2+), and release of NOsurrogate

ACE inhibitors directly activate bradykinin B1 receptors to release NO, representing a novel mechanism of action that may contribute to their therapeutic benefits and side effects.

Cite This Study

Ignjatovic et al. (2002) studied this question.

synapsesocial.com/papers/6a70fb0f75498292b70a7797 https://doi.org/10.1074/jbc.m200355200

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Novel Mode of Action of Angiotensin I Converting Enzyme Inhibitors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Novel Mode of Action of Angiotensin I Converting Enzyme Inhibitors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider