What question did this study set out to answer?

To determine whether non-HDL cholesterol level predicts cardiovascular disease in individuals with diabetes.

January 1, 2003Diabetes CareOpen Access

Non-HDL Cholesterol as a Predictor of Cardiovascular Disease in Type 2 Diabetes

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Why the study?

Does non-HDL cholesterol predict fatal and nonfatal cardiovascular disease in American Indian adults with diabetes?

Population

2,108 American Indian men and women aged 45-74 years with diabetes but no cardiovascular disease at…

Comparison

Non-HDL cholesterol level (highest tertile) vs Lower tertiles of non-HDL cholesterol, or other…

Design

Cohort

Follow-up

average 9 years

Authors

WLWeiquan LuUniversity of Vermont HRHelaine E. ResnickGeneral / Preventive / Lipids KJKathleen A. JablonskiGeorge Washington University

Discussion

Member takes

Implication

Non-HDL cholesterol may enhance CVD risk assessment in diabetes; hypothesis-generating and requires prospective validation before practice change.

Key Points

To determine whether non-HDL cholesterol level predicts cardiovascular disease in individuals with diabetes.
Prospective population-based cohort design (Strong Heart Study) analyzing 2,108 participants aged 45–74 years with diabetes and no baseline cardiovascular disease.
Baseline evaluations included interviews, physical examinations, and laboratory tests from 1989 to 1992, with fatal and nonfatal cardiovascular events tracked through December 1998 (average 9-year follow-up).
Multivariable analyses demonstrated non-HDL cholesterol strongly predicted cardiovascular disease and coronary events, with highest-tertile hazard ratios of 2.23 in men and 1.80 in women.
Non-HDL cholesterol hazard ratios exceeded those for LDL cholesterol and triglycerides alone in both sexes and remained predictive across a broad range of triglyceride concentrations.

Structured PICO

Does non-HDL cholesterol predict fatal and nonfatal cardiovascular disease in American Indian adults with diabetes?

Population

2,108 American Indian men and women aged 45-74 years with diabetes but no cardiovascular disease at baseline, from the Strong Heart Study (13 communities in 3 geographic areas in the U.S.).

Intervention

Non-HDL cholesterol level (highest tertile)

Comparator

Lower tertiles of non-HDL cholesterol, or other lipid measures (LDL cholesterol, triglycerides, total/HDL cholesterol ratio)

Outcome

Fatal and nonfatal cardiovascular diseasehard clinical

Non-HDL cholesterol is a strong predictor of cardiovascular disease in patients with diabetes, outperforming LDL cholesterol or triglycerides alone.

Cite This Study

Lu et al. (2003) studied this question.

synapsesocial.com/papers/6a70fb8c53da1ffdb507b152 https://doi.org/10.2337/diacare.26.1.16

Topics

Women and heart disease

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Implication

Non-HDL cholesterol may enhance CVD risk assessment in diabetes; hypothesis-generating and requires prospective validation before practice change.

Non-HDL Cholesterol as a Predictor of Cardiovascular Disease in Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Non-HDL Cholesterol as a Predictor of Cardiovascular Disease in Type 2 Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider