June 1, 1979Circulation

Ultrastructure and transmembrane potentials of cardiac muscle in the human anterior mitral valve leaflet.

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Population

Anterior mitral valve leaflet obtained from the heart of a recipient of a cardiac transplant (n=1)

Comparison

In vitro application of epinephrine… vs Baseline conditions

Design

Preclinical

Authors

Discussion

Mitral valve muscle may act as an arrhythmogenic focus; Level 5 data leaves open its clinical relevance pending in vivo confirmation.

Population

Anterior mitral valve leaflet obtained from the heart of a recipient of a cardiac transplant (n=1)

Intervention

In vitro application of epinephrine, acetylcholine, verapamil, and electrical stimulation

Comparator

Baseline conditions (absence of electrical stimulation or drugs)

Outcome

Ultrastructure and transmembrane potentials (maximum diastolic potentials, action potential characteristics, and impulse initiation)surrogate

Cardiac muscle in the human mitral valve can initiate electrical impulses and may serve as an arrhythmogenic focus.

Wit et al. (1979) studied this question.

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