What question did this study set out to answer?

Evaluate the clinical utilization patterns, administration timing, duration, and financial charges of antibiotic prophylaxis in surgical procedures.

February 20, 1981JAMA

Antimicrobial Prophylaxis in Surgical Patients

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Population

1,021 surgical patients from 27 hospitals in metropolitan Minnesota undergoing general, obstetric and…

Design

Cohort

Authors

KCKent CrossleyBoston University

Discussion

Member takes

Implication

Suboptimal prophylaxis timing and duration remain common; leaves open whether stewardship safely reduces costs and resistance.

Key Points

Evaluate the clinical utilization patterns, administration timing, duration, and financial charges of antibiotic prophylaxis in surgical procedures.
Prospective multicenter evaluation of surgical patients (N=1,021) across 27 hospitals in metropolitan Minnesota.
Tracked antibiotic selection, preoperative timing, duration of prophylaxis, and surgical categories including general (23%), orthopedic (26%), obstetric/gynecologic (13%), and urologic (12%) procedures.
Preoperative antibiotics were initiated within four hours before surgery in only 41% of patients, and 50% of prophylactic courses were administered for clean (class 1) procedures.
The mean duration of prophylaxis was 3.4 days, with approximately one third of patients receiving antibiotics for more than 72 hours (accounting for 65% of all antibiotic patient-days).
Cephalosporins were administered to over 50% of patients, and restricting prophylactic duration was estimated to reduce perioperative antibiotic drug charges by 18% to 50%.

Structured PICO

Population

1,021 surgical patients from 27 hospitals in metropolitan Minnesota undergoing general (23%), obstetric and gynecologic (13%), orthopedic (26%), and urologic (12%) procedures.

Intervention

Antibiotic prophylaxis (more than one half received a cephalosporin)

Outcome

Patterns of use of antibiotic prophylaxis (timing, duration, and cost)

A significant proportion of surgical antibiotic prophylaxis is administered suboptimally regarding timing and duration, presenting an opportunity for substantial cost savings.

Cite This Study

Kent Crossley (1981) studied this question.

synapsesocial.com/papers/6a70fdb13ce530166bc2fbbb https://doi.org/10.1001/jama.1981.03310320044024

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Antimicrobial Prophylaxis in Surgical Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Antimicrobial Prophylaxis in Surgical Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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