USPIO contrast agents can enhance cardiovascular MRI by providing blood pool contrast and acting as markers for cellular inflammation.
May enhance cardiovascular MRI inflammation imaging; leaves open prospective validation before clinical adoption.
Ultra-small superparamagnetic particles of iron oxide (USPIO) are iron-oxide based contrast agents that enhance and complement in vivo magnetic resonance imaging (MRI) by shortening T1, T2, and T2* relaxation times. USPIO can be employed to provide immediate blood pool contrast, or to act as subsequent markers of cellular inflammation through uptake by inflammatory cells. They can also be targeted to specific cell-surface markers using antibody or ligand labeling. This review will discuss the application of USPIO contrast in MRI studies of cardiovascular disease.
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Stirrat et al. (2014) studied this question.
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