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April 27, 2009Catheterization and Cardiovascular Interventions

Percutaneous closure of left atrial appendage to prevent embolic events in high‐risk patients with chronic atrial fibrillation

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Why the study?

Does percutaneous closure of the LAA using the PLAATO system prevent embolic events in high-risk patients with NV-AF and contraindications to anticoagulation?

Population

20 patients with non-valvular atrial fibrillation, contraindications to anticoagulant therapy, and high risk…

Design

Cohort

Follow-up

mean 40 +/- 10 months

Authors

GUGian Paolo UssiaMMMassimiliano MulèVCValeria Cammalleri

Discussion

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Overview

Hypothesis-generating for embolic prevention with PLAATO LAA closure in anticoagulation-ineligible NV-AF; randomized trials needed before adoption.

Structured PICO

Does percutaneous closure of the LAA using the PLAATO system prevent embolic events in high-risk patients with NV-AF and contraindications to anticoagulation?

P
Population
20 patients with non-valvular atrial fibrillation (NV-AF), contraindications to anticoagulant therapy, and high risk for cardioembolic stroke (mean CHADS2 score 3 +/- 1.2), mean age 69 +/- 8 years, 13 male.
I
Intervention
Percutaneous closure of the left atrial appendage (LAA) using the PLAATO system via transeptal access.
O
Outcome
Safety, feasibility, and long-term efficacy (prevention of embolic events).hard clinical

Percutaneous LAA closure using the PLAATO system appears safe and feasible, with no embolic events observed over a mean 40-month follow-up in a small cohort of high-risk NV-AF patients contraindicated for anticoagulation.

Cite This Study

Ussia et al. (2009) studied this question.

synapsesocial.com/papers/6a70fe9a3ce530166bc2fc11https://doi.org/10.1002/ccd.22099
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Percutaneous left atrial appendage transcatheter occlusion in patients with chronic nonvalvular atrial fibrillation: early institutional experience2006 · 10 citations
  2. 2Clinical outcomes three years after PLAATO implantation2007 · 42 citations
  3. 3Surgical left atrial appendage ligation is frequently incomplete: a transesophageal echocardiographic study2000 · 398 citations
  4. 4Transesophageal Echocardiographic Correlates of Thromboembolism in High-Risk Patients with Nonvalvular Atrial Fibrillation1998 · 516 citations
  5. 5A Novel Pacing Maneuver to Localize Focal Atrial Tachycardia2006 · 166 citations