Population
199 human enterovirus 71 (HEV71) strains isolated in the Netherlands between 1963 and 2008
Design
Other
Authors
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May explain HEV71 genogroup replacement via immune escape; leaves open optimal strain selection for cross-protective vaccines.
The global shift from HEV71 genogroup B to C in 1987 may be explained by the lack of cross-neutralization of C viruses by B2-induced antibodies, while global herd immunity against C1/C2 may restrict B4/C4 epidemics to the Asian Pacific region.
Sanden et al. (2010) studied this question.
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