March 26, 2004Journal of Biological ChemistryOpen Access

Preferential Translation of Internal Ribosome Entry Site-containing mRNAs during the Mitotic Cycle in Mammalian Cells

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Population

Mammalian cells

Design

Preclinical

Authors

XQXiaoli QinShanghai Jiao Tong University PSPeter SarnowStanford University

Discussion

Member takes

Implication

IRES may enable selective translation in mitotic cells; leaves open relevance to human cardiovascular proliferation or disease.

Structured PICO

Population

Mammalian cells

Intervention

Cell synchronization protocol (mitosis)

Outcome

mRNA translational efficiency and association with large polysomessurrogate

Specific IRES sequences are differentially regulated during mitosis, allowing approximately 3% of mRNAs to be actively translated despite global translational reduction.

Cite This Study

Qin et al. (2004) studied this question.

synapsesocial.com/papers/6a70ffce78a11c550e0b088e https://doi.org/10.1074/jbc.m312854200

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Bookmark

Preferential Translation of Internal Ribosome Entry Site-containing mRNAs during the Mitotic Cycle in Mammalian Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Preferential Translation of Internal Ribosome Entry Site-containing mRNAs during the Mitotic Cycle in Mammalian Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider