Answers are grounded in this paper and cite their sources.
A procedure is described that greatly simplifies the use of an oxazaborolidine catalyst derived from (1R,2S) cis-1-amino-indan-2-ol. This B-OMe catalyst has been employed in the asymmetric reduction of a number of structurally diverse prochiral ketones, in particular the reduction of alpha-amino acetophenone and its derivatives. A method for reducing the effective catalyst loading by "in situ recycling" is also presented. [structure: see text]
No takes yet. Share an insight, caveat, or question.
Gilmore et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: