Why the study?
Does retigabine increase the risk of urinary adverse events in adults with partial-onset seizures?
Population
Adults with partial-onset seizures from the overall phase 2/3 clinical development program
Comparison
Retigabine (ezogabine) as adjunctive therapy vs Placebo
Design
Review
Authors
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Urinary retention monitoring warranted with retigabine; confirms trial signals but leaves open real-world incidence and mitigation strategies.
Does retigabine increase the risk of urinary adverse events in adults with partial-onset seizures?
Retigabine is associated with an increased risk of urinary retention and related adverse events, consistent with its pharmacologic effect on bladder smooth muscle, warranting caution in at-risk patients.
Brickel et al. (2012) studied this question.
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