The formation of AICARle 2 from AIR, which has been shown by Levenberg and Buchanan (2) to be a step in the synthesis of inosinic acid by soluble enzymes of avian liver, was found to proceed through the intermediary formation of succino-AICAR as described in Paper XXIII(3) and illustrated by Reactions 1 and 2.
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Lukens et al. (1959) studied this question.
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