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Hepatosplenic candidiasis (HSC) or chronic disseminated candidiasis (CDC) is an invasive fungal infection that affects neutropenic patients. The Invasive Fungal Infectious Group of the European Organization for Research and Treatment of Cancer (EORTC-IFIG) and the Mycoses Study Group of the National Institute for Allergy and Infectious Diseases (MSG-NIAID) require peripheral, target-like abscesses on liver and/or spleen imaging in addition to elevated serum alkaline phosphatase levels for diagnosis of HSC [1]. Despite this standardized definition, consistent data yielding an estimated incidence is not yet available.
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A 2005 study studied this question.
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