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Chronic administration of high doses of amiodarone for long time induces in some patients in the light-exposed areas of skin a cutaneous deposition of pigment, which consists of lipofuscin-like lipochrom. Clinically a 73-year-old woman, who received for 5 years daily 200–600 mg amiodarone, showed a peculiar metallic-blue coloration of the face.
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H. Matheis (2009) studied this question.
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